Chromosome Stability 2016

Meeting will start from December 15th at noon and end on December 18th afternoon.

All talks are for 20 min. An extra 5 min is kept for discussion.

Programme Outline


12:00-14:00 Registration and Lunch
14:00-14:10 Inauguration / Introduction
Speaker/Affiliation Title
Session I, DNA Replication-Repair-Recombination – I (Dana Branzei and Umesh Varshney)
14:15 – 14:35 Bernard de Massy, Institute of Human Genetics, France The programmed induction of meiotic DNA double strand breaks: Where and how?
14:40- 15:00 K. Muniyappa, IISc, Bangalore A Novel Holliday Junction Resolvase from Mycobacterium tuberculosis
15:05 – 15:25 Michael Lichten, NIH, USA Recombination intermediate metabolism in yeast
15:30 – 15:50 Nishant K.T, IISER Thiruvananthapuram The effect of variations in meiotic crossover frequency on chromosome segregation
16:00 – 16:30 Tea
16:30 – 16:50 Paula Cohen, Cornell University, USA Mechanisms of crossover control in mammalian meiosis
16:55 – 17:15 Rajeev Kumar, Institut Jean-Pierre Bourgin, France Regulation of meiotic recombination by the Figl1/AAA-ATPase complex
17:20 – 17:40 Akira Shinohara, Osaka University, Japan Cleavage-independent removal of cohesin from chromosome arms during late prophase I of meiosis
17:45 – 18:05 Scott Keeney, Memorial Sloan Kettering Cancer Centre, USA Breaking and Chewing DNA in meiosis
18:15- 19:45 Poster Session I (Odd number posters)
20:00 – 21:00 Dinner


Speaker/Affiliation Title
Session II, Chromosome Structure and Organization (Jennifer Surtees and Muniyappa K)
9:00-9:20 Joseph Heitman, Duke University, USA Hypermutators and the evolution of human fungal pathogens
9:25-9:45 Karl Kuchler, Medical University Vienna, Austria Histone modifications in fungal pathogens - a forgotten player in antifungal drug discovery
9:50 – 10:10 Christophe d’Enfert, Institut Pasteur, Paris, France Loss of heterozygosity in the fungal pathogen Candida albicans: occurrence, constraints, and regulation
10:15 – 10:35 Devyani Halder, CDFD, Hyderabad Fission yeast sirtuin Hst4 functions in preserving genomic integrity by regulating a replisome component
10:40 – 11:10 Tea
11:10- 11:30 DN Rao, IISc, Bangalore N4 cytosine DNA methylation epigenetically regulates gene expression and pathogenesis of Helicobacter pylori
11:35-11:55 Amartya Sanyal, NTU, Singapore Epigenetic states define the gene signature in cancer chemoresistance
12:00-12:20 B.J Rao, TIFR, Mumbai ATR kinase self-attenuates itself in Replication Fork Recovery in mammalian cells
12:25- 12:45 Shweta Tyagi, CDFD, Hyderabad A histone methyltransferase regulates chromosome congression: New role for MLL in mitosis
12:50-14:00 Lunch
Session II, Chromosome Structure and Organization
14:00 – 14:20 Andrés Aguilera, University of Seville, Spain Molecular basis of RNA mediated genome instability
14:25 – 14:45 Lucas Argueso, Colorado State University, USA Both R-Loop removal and ribonucleotide excision repair activities of RNase H2 contribute substantially to chromosome stability
14:50 – 15:10 Umesh Varshney, IISc, Bangalore Two unusual members of the uracil DNA glycosylase family
15:15-15:30 Group Photo
15:30 – 16:00 Tea
16:00- Free evening, dinner on your own


Speaker/Affiliation Title
Session III, DNA Replication-Repair-Recombination – II (Harmit Malik and Santanu Ghosh)
9:00 – 9:20 Jim Haber, Brandeis University, USA Creating and dealing with heterologies during repair of a broken chromosome
9:25 – 9:45 Sathees Raghavan, IISc, Bangalore DNA Double-strand Break Repair in Penaeus monodon is Predominantly Dependent on Homologous Recombination
9:50 – 10:10 Eric Alani, Cornell University, USA Activation of a DNA mismatch repair endonuclease that functions in meiotic crossing over
10:15 -10:35 Dana Branzei, IFOM-IOE, Italy Replication and DNA damage tolerance mechanisms at natural pausing sites
10:40-11:10 Tea
11:10-11:30 Nagaraja V, JNCASR/IISc, Bangalore The Achilles’s heel of the topoisomerase reaction as a tool for genome-wide action
11:35- 11:55 Benu Brata Das, IACS, Kolkata New regulators of DNA Topoisomerase I-induced DNA damage and repair
12:00- 12:20 Marc Drolet, University of Montreal, Canada Involvement of type 1A topoisomerases in replication from R-loops in E. coli.
12:25 – 12:45 Sreenivasulu Kurukuti, University of Hyderabad, Hyderabad Dynamic reorganization of intra-chromosomal domains accompanies signal induced lactogenic differentiation of mouse mammary epithelial cells
12:50 – 14:00 Lunch
Session IV, Chromosome Segregation (Lucas Argueso and Nagaraja V)
14:00-14:20 Harmit Malik, Fred Hutchinson Cancer Research Center, USA Causes and consequences of genetic innovation of centromeric proteins
14:25- 14:45 Jeyaprakash Arulanandam, University of Edinburgh, UK Molecular Basis for Mis18 Assembly Required for Centromere Inheritance
14:50 – 15:10 Tats Fukagawa, Osaka University, Japan Epigenetic regulation for kinetochore specification and assembly in vertebrates
15:15-15:35 Kaustuv Sanyal, JNCASR, Bangalore Centromere evolution in basidiomycetes
15:40-16:10 Tea
16:10-16:30 Raja Paul, IACS, Kolkata Tinkering microtubule chromosome interaction to unravel spindle stability during mitosis
16:35- 16:55 Santanu Ghosh, IIT-Bombay, Mumbai Molecular Motors : Functions in chromosome stability during meiosis in yeast
17:00-17:20 Tapas Manna, IISER Thiruvananthapuram Kinetochore capture by spindle microtubules: role of plus tip localizing signal motif
17:25-17:45 Arshad Desai, UC San Diego, USA New Horizons for the Chromosome Segregation Machinery
18:00- 19:30 Poster Session II (Even number posters)
19:30 Banquet Dinner


Speaker/Affiliation Title
Session V, DNA Replication-Repair-Recombination – III (Christophe d’Enfert and Srinivasa Murty)
9:00 – 9:20 Wolf Heyer, University of California, Davis, USA Recombination-mediated Multi-Invasions induce chromosomal rearrangements
9:25 – 9:45 Ganesh Nagaraju, IISc, Bangalore ATR signaling uncouples role of XRCC2 in Homologous Recombination and replication stress response
9:50 – 10:10 Jennifer Surtees, University of Buffalo, USA Msh2-Msh3: a tipping point between genome stability and instability
10:15 – 10:35 Sagar Sengupta, NII, New Delhi Mechanisms linking DNA damage response to DNA repair processes
10:40 – 11:10 Tea
11:15 – 12:30 Discussion
12:30 – 12:45 Concluding session, poster prizes
13:00 – 14:00 Lunch and Departure

Poster presenters:

Please restrict your poster size to 1 m wide x 1 m high. Board pins will be provided.
Please display your poster by 2 pm on 15 December and remove it just before lunch on 18 December.
The exact date and time for your session will be uploaded on the website.